E. Kasteel

Extrapolation steps in quantitative in vitro to in vivo extrapolation to advance in vitro-based chemical risk assessment for human health

The transition towards Next Generation Risk Assessment (NGRA) aims at increasing human relevance and efficiency of chemical risk assessment, by using human-based in vitro and in silico methods. Quantitative in vitro to in vivo Extrapolation (QIVIVE) is central to this approach and enables the derivation of health-based...