Open access
Aug 2026
Locus-specific gene-context interactions improve polygenic prediction
Polygenic scores (PGS) are a primary output of large-scale genetic studies and are being deployed in clinical and non-clinical settings. However, current PGS assume simple additive models that ignore context-specific genetic effects, which likely reduce their accuracy and robustness. To address this, we developed PGSC,...
Renée Fonseca, C. Caggiano, Manuela Costantino et al.
· bioRxiv · 1 citation