Е. Knyazeva

DIGITAL TWIN OF DRUG-INDUCED LIVER INJURY AND SYSTEMIC ADVERSE DRUG REACTIONS IN MASS MEDICATION SCENARIOS: PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS

The expansion of self-medication, broad over-the-counter drug availability, seasonal surges in symptomatic medication use, and polypharmacy have made drug-induced liver injury and systemic adverse drug reactions a problem of both clinical medicine and medicinal chemistry. The aim of this re-view is to propose a digital...