External Evaluation of Multi-Omics Prognostic Models Across TCGA-BRCA and METABRIC: Transportability, Stability, and Incremental Performance
Cross-cohort evaluation of multi-omics prognostic models can fail because molecular features are not assayable, fitted models do not transport, feature selection is unstable, or molecular data add little beyond clinical predictors. We used a dual-track evaluation design with TCGA-BRCA as the source cohort and METABRIC...