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Open access Sep 2026

External Evaluation of Multi-Omics Prognostic Models Across TCGA-BRCA and METABRIC: Transportability, Stability, and Incremental Performance

Cross-cohort evaluation of multi-omics prognostic models can fail because molecular features are not assayable, fitted models do not transport, feature selection is unstable, or molecular data add little beyond clinical predictors. We used a dual-track evaluation design with TCGA-BRCA as the source cohort and METABRIC...

E. Krikun, Abedalrhman Alkhateeb · 0 citations
Open access Oct 2026

Design and outcome-model estimability in doubly robust survival analysis: a breast cancer reanalysis

Doubly robust survival estimators require nuisance models that the available information can support. We examine design and estimator dependence in TCGA breast cancer data. Treatment indicators disagree for 337 of 1076 patients; 67.4% have unobserved five-year binary outcomes; and receptor imputation expands the triple...

W. Fahmy, E. Krikun, A. Al Khateeb · 0 citations

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