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Evgeny Z. Kvon

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Review Open access Aug 2026

Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo

Enhancers control tissue-specific gene expression across animals1. Although deep learning2,3 has enabled enhancer prediction and design in mammalian cell lines and non-mammalian model organisms4, 5, 6, 7, 8, 9–10 (reviewed in a previous publication11), it remains unclear whether such approaches can operate within the r...

Shen-Zhi Chen, Vincent Loubière, Ethan W. Hollingsworth et al. · 1 citation
Open access Aug 2026

Systems genetics approaches model the heritable architecture of polyendocrine metabolic ovarian syndrome.

It is shown that increased ovarian area contributes to both PMOS susceptibility and ovarian cancer progression, while specific ovary-heart signaling circuits modulate cardiac function with aging, and SF3B1-mediated splicing is uncovered as a link between ovary function and systemic metabolism.

Christy M. Nguyen, L. Velez, Youngseo Cheon et al. · 0 citations

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