The advent of pan-RAS and allele-specific inhibitors in clinical trials have created an urgent need to understand how RAS inhibition remodels the pancreatic immune microenvironment and alters anti-tumor immunity, to guide rational combinations with immunotherapy.
We used a murine model with pancreas-specif...
Rashmi J. Kumar, E. Lasse-Opsahl, Lauren Gerbereux et al.· Cancer Research· 0 citations
Notch is a contact-dependent signaling pathway that plays critical roles in spatiotemporal patterning during embryogenesis. Beyond its role in development, Notch signaling regulates tissue patterning in adult organs in response to tissue injury or cancer. In the context of cancer, the role of Notch signaling has been...
Allison C. Bischoff, Wei Yan, Carlos E. Espinoza et al.· Cancer Research· 0 citations
The findings reveal distinct metastatic microenvironments in liver and lung characterized by coordinated differences in tumor subtype composition and myeloid phenotype, highlighting the importance of local immune landscapes in shaping metastatic disease biology.
E. Lasse-Opsahl, Daksh Thakkar, Julie M. Clark et al.· Cancer Research· 0 citations
It is suggested that pharmacologic and genetic KRAS inhibition differentially remodel the intratumoral T cell compartment, whereas both induce similar T cell changes within the liver premetastatic niche.
Lauren Gerbereux, Rashmi Kumar, E. Lasse-Opsahl et al.· Cancer Research· 0 citations
A GSTT1HighCD133High stem-like subpopulation in metastatic PDA is identified and an FGFR-dependent signaling axis that sustains this state is identified, representing a potential therapeutic vulnerability.
Delgado Herrera Deborah de la Caridad, Alejandro Arroyo Roman, Riyan N. Campbell et al.· Cancer Letters· 0 citations
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