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Author

E. Lion

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Open access Aug 2026

IL-15 boosts mesothelin- and CD70-CAR NK cell potency in PDAC without added benefit from dual targeting

Chimeric antigen receptor (CAR) therapies have shown great success in hematological malignancies but remain largely ineffective against solid tumors such as pancreatic ductal adenocarcinoma (PDAC). A key obstacle among various aspects, is the dense stromal barrier formed by cancer-associated fibroblasts (CAFs), providi...

Laura Gehrcken, J. Ott, Astrid Van Den Eynde et al. · 0 citations
Review Open access Aug 2026

Inflammatory mechanisms in the AML bone marrow niche: From pathogenesis to therapy.

This review summarizes the current knowledge on inflammatory cytokines and signaling pathways in AML, focusing on their mechanisms of action and implications for immune tolerance and clonal hematopoiesis and the emerging therapeutic strategies targeting these pathways to improve clinical outcomes for patients with AML.

Toon Suls, E. Lion, Florian Van Oers et al. · 0 citations

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