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Author

E. M. El-Fakharany

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Open access Sep 2026

Synthesis and in silico studies of hexahydroacridine derivatives as potential antitumor agents

The anticancer potential of newly synthesized hexahydro-1,8-acridinedione derivatives featuring strategic structural modifications at positions 9 and 10 is evaluated, establishing compound 4d as a promising multi-target lead scaffold, warranting further optimization toward selective anticancer therapeutics.

E. El-Helw, S. Hammad, Hassan A. Khatab et al. · 0 citations
Aug 2026

Statistical optimization of extracellular antimicrobial metabolite production by Streptomyces enissocaesilis ASB isolate targeting multidrug-resistant pathogens

Findings highlight S. enissocaesilis ASB as a promising source of extracellular bioactive metabolites and provide a foundation for future studies involving compound purification, structural characterization, safety evaluation, and translational development against MDROs.

A. Badawy, E. M. El-Fakharany, Jehan S. Albrahim et al. · 0 citations

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