Pyridobenzothiazolones (PBTZs) are tricyclic compounds originally investigated as chemotypes directed against viral RNA-dependent RNA polymerases. Following the first reports on hepatitis C virus (HCV) NS5B inhibition, medicinal chemistry optimization and mechanistic studies have expanded the antiviral profile of this...
Francesca Speranza, Claudia Massa, F. Cossu et al.· European journal of medicina...· 0 citations
Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501). Acc...
F. Cossu, Serena Virili, Bianca Braggiotti et al.· Protein Science· 0 citations
Results support a model in which ErsA serves as a central, c-di-GMP-responsive regulatory hub, linking envelope stress responses to c-di-GMP cascades to fine-tune key extracytoplasmic functions and coordinate biofilm formation.
S. Ferrara, T. Brignoli, Silvia Santoro et al.· Nucleic Acids Research· 0 citations
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