54. Development of therapeutics for neurodegenerative diseases via CTL1-targeted induction of M1-to-M2 microglial polarization
Abstract Background Microglia are central regulators of neuroinflammation in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). In these conditions, pathological stimuli including lipopolysaccharide (LPS) and amyloid-β (Aβ) peptides promote a phenotypic switch from neuroprotective...