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Author

E. Mylonakis

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Open access Aug 2026

Nirmatrelvir-ritonavir targeting viral persistence in post-COVID-19 condition (long COVID) in the USA (RECOVER-VITAL): a randomised, double-blind, placebo-controlled, phase 2 trial.

BACKGROUND Post-acute sequelae of SARS-CoV-2 infection, more commonly known as long COVID, has emerged as a major health problem. The pathogenesis of long COVID is unknown, but among the leading hypotheses is viral persistence. We aimed to investigate whether the use of the SARS-CoV-2 antiviral nirmatrelvir-ritonavir i...

L. Baden, N. Shah, Sean T. H. Liu et al. · 0 citations
Open access Aug 2026

Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection

This work identifies VCP as a druggable node for host-directed immunomodulation and highlights SKI-II as a prototype small molecule that boosts host tolerance to infection, thereby validating the C. elegans-based screening platform for discovering immunomodulators active in mammalian systems.

Li-Yang Zhang, Kai Ye, Charilaos Dellis et al. · 0 citations

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