Author

E. Nollen

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Review Open access Oct 2026

Cellular and systemic modifiers of alpha-synuclein proteostasis

Abstract Ageing is a primary risk factor for neurodegenerative disorders, including Parkinson's disease (PD). As individuals age, their cells become less efficient in maintaining protein homeostasis, leading to an increased likelihood of protein misfolding and aggregation. A hallmark of PD and other synucleinopathies i...

Suzanne Couzijn, Anna P. Ainslie, Alejandro Herron-Bedoya et al. · Philosophical transactions o... · 0 citations

Open access Sep 2026

A PPARγ-like signalling axis integrates lipid homeostasis and mitochondrial quality control to preserve neuronal integrity

Peroxisome proliferator-activated receptor gamma (PPARγ) is a central regulator of lipid metabolism and a critical mediator of neuroprotection, yet the mechanisms linking these functions remain unclear. Here, we identify the Caenorhabditis elegans nuclear receptor SEX-1 as a functional PPARγ-like regulator and define a...

Dikaia Tsagkari, Maria Markaki, Tao Zhang et al. · bioRxiv · 0 citations