ABSTRACT Resistance of lung cancer to EGFR‐targeting tyrosine kinase inhibitors (TKIs) like osimertinib frequently results from secondary mutations or activation of bypass signaling pathways. Re‐analysis of clinical data unveiled elevated expression of GAS6 and its receptor MERTK in lung cancer patients developing resi...
Suvendu Giri, Boobash-Raj Selvadurai, Nitin Gupta et al.· Advancement of science· 0 citations
STP-BENCH is presented, a standardized benchmark for virtual ST models and systematically examines which genes and gene sets are recoverable from histomorphology, and evaluates the downstream biological utility of predicted profiles through cell-type deconvolution and spatial domain identification.
Youngmin Chung, Hun-Ha Ji, Andrew H. Song et al.· 0 citations
An integrated proteogenomic pipeline combining single-cell RNA sequencing, combinatorial optimization, mass spectrometry–based proteomics, and immunohistochemistry is developed to systematically map the SCLC surfaceome of 49 tumors across 25 patients with relapsed SCLC and found claudin-3 (CLDN3) to be a consistently e...
Brett Schroeder, Jaehyun Choi, Alejandro A. Schäffer et al.· bioRxiv· 0 citations
Short Precise-Encodable ADAR Recruiting (SPEAR) gRNAs are developed that harness endogenous ADAR1 to direct precise adenosine-to-inosine (A-to-I) editing at selected transcript sites and demonstrate the generation of immunogenic neoepitopes through RNA editing at the transcript level, termed editopes.
R. Pecori, Beatrice Casati, Rona Merdler-Rabinowicz et al.· EMBO Journal· 0 citations
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