Metabolomic Profiles Indicate Variable Tolerance to Hypoxia in Newborn Piglets: An Experimental Study of Low Dose Nicotine After Global Hypoxia.
INTRODUCTION Treatment of hypoxic-ischemic encephalopathy (HIE) remains incomplete. This study aimed to characterise metabolomic changes induced by severe hypoxia and assess whether low-dose intravenous nicotine could modify these changes. We aimed to explore whether piglets with decreased hypoxia tolerance (DHT) displ...