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Author

E. Schönbrunn

2 papers indexed here

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Open access Aug 2026

Unc-51 like kinase 3 (ULK3) contributes to autophagy and cell survival in multiple myeloma

Despite effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. Analysis of RNA sequencing data from CD138 + MM patient cells (n = 813) across disease stages identifies an autophagy gene signature. Particularly elevated ULK3 expression is strongly associated wi...

Marilena Tauro, Tao Li, P. Sudalagunta et al. · 0 citations
Jul 2026

Abstract A053: Discovery and modular design of CDK12–DDB1 molecular glues for targeted Cyclin K degradation

Advanced lead molecules across these series achieve a rare combination of high CDK12/13 selectivity, potent and durable cyclin K degradation, and favorable physicochemical, in vitro ADME, and in vivo PK properties, supporting progression toward IND-enabling preclinical safety evaluation.

Thiyagamurthy Pandurangan, Anna Iermolaieva, Pompom Ghosh et al. · 0 citations

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