Author

E. Sigurdsson

2 papers indexed here

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Open access Oct 2026

Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment

Pathological tau disrupts neuronal activity and brain function in Alzheimer’s disease and other tauopathies. However, the underlying mechanisms for neuronal network dysfunction remain largely unknown. Using human inducible pluripotent stem cell (iPSC) - derived neurons, we show that the familial MAPT P301L mutation lea...

Chang-Yi Ji, Yunlu Zhu, Hediye Erdjument-Bromage et al. · bioRxiv · 0 citations

Open access Jul 2026

A single-domain antibody targets aggregation-prone region of α-synuclein to reduce synucleinopathy, rescue neurodegeneration and improve function

The therapeutic potential of five anti-α-syn single-domain antibodies to clear pathological α-syn in mouse neuronal culture is evaluated and their in vivo efficacy is demonstrated in a Drosophila model of synucleinopathy.

Pragati, E. E. Congdon, Yixiang Jiang et al. · bioRxiv · 0 citations