Author

E. Smits

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#diffusion models Review Open access Sep 2026

Immunogenic Cell Death in Melanoma Induced by Radiotherapy, Photodynamic Therapy, or Non-Thermal Plasma: The Role of Reactive Oxygen and Nitrogen Species

Melanoma is characterised by profound immune evasion, and although immune checkpoint inhibitors (ICIs) have transformed clinical management, durable responses remain limited to a subset of patients. Therapies that induce immunogenic cell death (ICD) can enhance anti-tumour immunity by converting dying tumour cells into...

Lisa Van der Heyden, Steve Vanlanduit, E. Smits et al. · Biomedicines · 0 citations

Open access Aug 2026

IL-15 boosts mesothelin- and CD70-CAR NK cell potency in PDAC without added benefit from dual targeting

Chimeric antigen receptor (CAR) therapies have shown great success in hematological malignancies but remain largely ineffective against solid tumors such as pancreatic ductal adenocarcinoma (PDAC). A key obstacle among various aspects, is the dense stromal barrier formed by cancer-associated fibroblasts (CAFs), providi...

Laura Gehrcken, J. Ott, Astrid Van Den Eynde et al. · Molecular therapy. Oncology · 0 citations