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Review Open access Aug 2026

Quality of Outcome Reporting for Older Subgroups in FDA Registration Gastroesophageal Cancer Trials (2010–2024): A Systematic Review

Simple Summary Older adults are commonly excluded from drug trials, causing physicians to make treatment decisions based on younger and fitter patients, which may lead to inadequate treatment of older patients. This study assesses publications from practice-changing drug trials in gastroesophageal adenocarcinoma from 2...

Ilse Trip, Martha Kormi, E. Smyth et al. · 0 citations
Review Open access Sep 2026

Current and Emerging Targeted Therapy in Advanced Gastroesophageal Adenocarcinoma

Novel targeted agents, particularly to HER2 and CLDN18.2, have demonstrated survival benefit despite ongoing challenges, and VEGFR2 inhibition with ramucirumab remains a cornerstone in later lines, while novel VEGF/PD-1(L1) bispecifics are under investigation.

O. Oakley, U. Mahmood, Yusuf Ahmad et al. · 0 citations

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