Abstract A017: Collagen stiffness shapes the stromal microenvironment architecture in pancreatic cancer in vitro models
Pancreatic ductal adenocarcinoma (PDAC) desmoplasia arises from pancreatic stellate cell (PSC) activation and progressive collagen I deposition, driving extracellular matrix (ECM) stiffening that sustains tumor progression, immune evasion, and therapy resistance. Current 2D and organoid models still poorly capture ho...