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E. Spodine

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Open access Sep 2026

Synthesis, characterization, crystal structures, antitumor activity, and computational study of novel thiosemicarbazone derivatives from thiazol-2/5-carbaldehyde

Twelve new thiazol-carbaldehyde thiosemicarbazone derivatives were synthesized by condensing the thiosemicarbazide derivative with the respective thiazol-2/5-carbaldehyde in methanol. The synthesized compounds were characterized by elemental analysis, ESI-mass spectrometry and FT-IR, 1H, 13C and 19F NMR spectroscopy. E...

Wilfredo Hernández, Fernando Carrasco, A. Vaisberg et al. · 0 citations

Synthesis, characterization, crystal structures, antitumor activity, and computational study of novel thiosemicarbazone derivatives from thiazol-2/5-carbaldehyde

HOMO – LUMO and global reactivity analyses indicate that compounds 3 and 6 possess higher chemical reactivity and exhibit lower kinetic stability than the reference inhibitor BI2536 of the Polo-like kinase 1.

Wilfredo, Fernando Carrasco, A. Vaisberg et al. · 0 citations

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