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Author

E. Strayer

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Open access Sep 2026

Beyond codon optimality: codon pairs regulate mRNA stability dependent on translation

The coding sequence of an mRNA directs its own decay, yet how codons, codon context, and amino acids collectively regulate mRNA stability remains poorly understood. Here we use a massively parallel reporter assay to decode this regulatory layer in zebrafish embryos. We find that codon pairs and amino acid pairs regulat...

Haejeong Lee, D. Musaev, Charles E. Vejnar et al. · 0 citations

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