Author

E. Troian

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Open access Oct 2026

Two potent, functionally redundant MazF toxins inactivate the 16S rRNA anti-Shine-Dalgarno sequence and are differentially expressed in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) remains a major global health threat, sustained by lengthy, multidrug treatment regimens that promote poor compliance and antibiotic resistance. The pathogen’s ability to evade clearance is facilitated in part by a transition to a nonreplicating, persistent state, a process thought to i...

Timothy W. Sherrier, E. Troian, Unnati Chauhan et al. · bioRxiv · 0 citations

Open access Oct 2026

Rationally tailored antibiotic selection circumvents toxin-mediated evasion of killing in Mycobacterium abscessus

Among clinically important non-tuberculous mycobacteria, Mycobacterium abscessus (Mab) has a large and highly dynamic accessory genome within an open pangenome, contributing traits that enhance drug resistance, bacterial persistence, stress survival, metabolic flexibility, and/or virulence. Defining how accessory l...

Nikita H. Amin, E. Troian, N. Woychik · Frontiers in Tuberculosis · 0 citations

Open access Oct 2026

Acquisition of a toxin-antitoxin system within a mobile genetic element likely enhances Mycobacterium abscessus fitness by enforcing cargo retention

The findings uncover the mechanism for durable expansion of the Mab accessory genome and suggest a selective advantage whereby toxin-mediated entry into a reversible growth-arrested state may reduce antibiotic susceptibility.

Nikita H. Amin, E. Troian, Heather M. Maldonado et al. · mSystems · 0 citations