The combination of the ATR inhibitor berzosertib with carboplatin demonstrated a lower ORR and more frequent ≥ grade 3 TrAEs compared with docetaxel + carboplatin in this heavily pretreated, biomarker-unselected mCRPC population.
A. Choudhury, C. Zhong, Wan-Ling Xie et al.· Cancer Research Communicatio...· 0 citations
Across three cohorts, higher ARNT expression correlated with higher BHS, and a consistent correlation was observed between ARNT and EPAS1 and HIF1A expressions, and a consistent correlation was observed between ARNT and EPAS1 expressions.
Wassim Daoud Khatoun, Ali Hajj Ali, Eddy Saad et al.· The Oncologist· 0 citations
Renal cell carcinomas (RCC) comprise multiple molecularly distinct cancers but most are treated empirically with therapies designed for clear cell RCC (ccRCC), the most common subtype, due to incomplete understanding of subtype-specific biology. We analyzed single-cell transcriptomes and chromatin accessibility profile...
Prathyusha Konda, Alexandra J. Wakolbinger, Yan-Tong Cui et al.· Nature Communications· 0 citations
A complex germline architecture underlying susceptibility and molecular subtype in young-onset lung cancer is delineated, consistent with additive risk from rare and common variants.
J. LoPiccolo, Ryan L. Collins, Noah Fields et al.· medRxiv· 0 citations
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