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Author

E. V. van Zwet

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Open access Oct 2026

Circulating microRNAs reflect hemorrhagic MRI markers in cerebral amyloid angiopathy.

BACKGROUND Cerebral amyloid angiopathy is a major cause of intracerebral hemorrhage in older individuals. Although cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) aid MRI diagnosis they offer limited pathophysiological insight. MicroRNAs (miRs) regulate microvascular function and may serve as nonin...

J. Duijs, E. Koemans, N. Verwey et al. · 0 citations
Open access Oct 2026

Blood cell composition reveals distinct biological interpretation of DNA methylation age and age acceleration

Epigenetic clocks are widely applied biomarkers of biological age, but their biological underpinnings remain unclear. We previously showed that epigenetic clocks are affected by naïve and memory T cell proportions, suggesting blood cell composition as a potential driver. However, analysis of cell composition is complic...

Thomas H. Jonkman, Anne Richmond, R. Marioni et al. · 0 citations
Open access Sep 2026

Machine learning versus conventional methods for prehospital detection of stroke due to large vessel occlusion or intracranial haemorrhage.

INTRODUCTION Adequate prehospital triage of anterior-circulation LVO (aLVO) or ICH enables direct allocation to appropriate stroke centres. Traditional triage based on clinical scales or logistic regression may miss complex predictor interactions, whereas machine learning approaches may improve diagnostic accuracy. We...

B. L. Garcia, L. Dekker, René Bekker et al. · 0 citations
Open access Aug 2026

DNA methylation signal of birthweight generalizes to high-risk pregnancies and is independent of genetic, maternal, and obstetric factors: a twin study

DNA methylation is associated with individual differences in birthweight in a high-risk clinical population of MC twins, independent of shared genetic, familial, maternal, and obstetric factors.

M. Sulaiman, L. Franken, J. A. Spekman et al. · 0 citations

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