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Author

E. Zeggini

3 papers indexed here

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Open access Aug 2026

Diet-responsive proteogenomic effects following short-term restriction of animal products in humans

The effect of diet on genetic regulation in humans remains largely unexplored. Here, we investigate gene-diet interactions in a unique group of healthy individuals (N = 200) who alternate between omnivory and dietary restriction of animal products for religious reasons. Using longitudinal proteomic and genotype data, w...

Alexandros Simistiras, O. Bocher, C. Emmanouil et al. · 0 citations
Open access Sep 2026

Genetic variation in HLA, IGKV, and HHEX loci influences mRNA vaccine-induced humoral protection against COVID-19.

Humoral immune responses to COVID-19 vaccination vary widely across individuals, yet the genetic determinants of functional antibody protection beyond binding antibodies after two immunizations remain poorly understood. We performed genome-wide association studies on antigen-specific antibody concentrations and live-vi...

B. Puzek, P. R. Wratil, C. Janke et al. · 0 citations
Open access Sep 2026

Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes

These findings identify shared genetic loci between T2D and neurodegenerative dementia, revealing systemic metabolic-neurodegenerative trade-offs and highlighting key genes that underpin the comorbidity, providing a framework for improved understanding of age-related multi-morbidity.

A. Arruda, Archit Singh, O. Bocher et al. · 0 citations

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