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E. Zhang

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Open access Sep 2026

A Study on the Regulation of PD-L1 Immune Escape by Gastric Cancer CAF Subsets Based on Metabolic Heterogeneity through Lactation Modification

High-glycolytic iCAFs in the gastric cancer tumor microenvironment exhibit significant metabolic heterogeneity and can secrete large amounts of lactate through the reverse Warburg effect, thus constructing an immunosuppressive microenvironment. Lactic acid is transported into tumor cells via MCT1 and regulates PD-L1 ex...

E. Zhang · 0 citations

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