Author

Édouard Louis

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Open access Sep 2026

Cell-type specific analyses in blood and gut identify cis-eQTL matching 140 IBD risk loci and entrectinib as repurposing candidate

Genes whose expression is affected, in a consistent manner, by GWAS-identified risk variants and the disease process, constitute preferred drug targets. We herein combine cis-eQTL analysis in 27 sorted blood cell populations and 43 intestinal cell types identified by single cell RNA-Seq in the ileum, colon and rectum,...

H. Perée, Viacheslav A. Petrov, Y. Tokunaga et al. · Nature Communications · 0 citations

Open access Aug 2026

NKCC1 as a regulator of stemness and redox balance in colorectal cancer

Na⁺-K⁺-2Cl − cotransporter 1 (encoded by SLC12A2 ) is a solute carrier overexpressed in colorectal cancer (CRC), but its functional role remains unclear. Here, we identify NKCC1 as a marker of normal intestinal stem cells, supported by its crypt-base localization, single-cell transcriptomics, and patient-derive...

P. Adam, C. Salée, Pauline Bomboire et al. · Oncogenesis · 0 citations