Author

Edouard Louis

2 papers indexed here

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Clinical trial Oct 2026

Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.

BACKGROUND Monoclonal antibodies targeting the interleukin-23 pathway are effective in treating inflammatory bowel disease. However, these therapies must be administered intravenously or by subcutaneous injection. METHODS We conducted a phase 2b, double-blind, randomized trial of oral icotrokinra, a peptide that bloc...

M. Abreu, B. Siegmund, L. Surace et al. · New England Journal of Medic... · 0 citations

Open access Aug 2026

Multi-level aggregation analysis of microbiome composition and host gene expression reveals associations with systemic and local immunity

Multi-level associations are identified between microbiome composition and host gene expression in both intestinal tissues and immune cells, suggesting potential mechanisms by which microbiota shape local and systemic immunity and vice versa.

L. Shagam, Anna Elizarova, Y. Momozawa et al. · Microbiology spectrum · 0 citations