Author

Eduardo Bravo

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Review Open access Jul 2026

Targeting Bruton’s Tyrosine Kinase in CLL: Selectivity, Resistance Mechanisms, and Emerging Therapeutic Strategies

A summary of the design of irreversible inhibitors, reversible inhibitors, and Proteolysis-targeting chimera (PROTAC) degraders targeting BTK is provided and how the design of these inhibitors and PROTACs leads to a more selective inhibition and degradation of BTK is reviewed.

Eduardo Bravo, C. C. Pastrana, Erica N Lamkin et al. · Cells · 0 citations