Author

Eduardo Cruz-Hinojoza

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Sep 2026

Abstract B084: Tracking tumor-specific CD4 T cells in pancreatic cancer reveals an essential role for cognate interactions with myeloid cells in remodeling the tumor microenvironment following immunotherapy

Our study identified an antigen (Ag)-specific CD4 T cell population in a preclinical orthotopic model of pancreatic ductal adenocarcinoma (PDA) that, upon expansion, elicited robust antitumor control. We developed an affinity-enhanced MHC-II tetramer to follow the endogenous tumor-specific CD4 T cells during pancreat...

Eduardo Cruz-Hinojoza, Zoe C. Schmichen, Sindri M. Bonner et al. · Cancer Research · 0 citations

Open access Aug 2026

Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapy

T tumor-specific CD4 T cells are central mediators of effective immunotherapy in solid tumors, and human immunotherapy transcriptomics shows conserved Th1 programming and Treg destabilization as a feature of response.

Eduardo Cruz-Hinojoza, Zoe C. Schmiechen, Sindri M. Bonner et al. · bioRxiv · 0 citations