Author

Ehab A. M. El-Shoura

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Sep 2026

Neuroprotective effects of dapansutrile in rotenone-induced parkinsonism: targeting NLRP3/caspase-1, NF-κB, Nrf2/HO-1, and PINK1/Parkin pathways.

S. M. Alqahtani, Basel A. Abdel-Wahab, Ehab A. M. El-Shoura et al. · InflammoPharmacology · 0 citations

Open access Aug 2026

Ivabradine alleviates the cisplatin-induced cardiotoxicity in rats through regulating the crosstalk between MLCP/PKG, MEK/ERK pathways and miRNA-34a levels

IVA significantly attenuates Cis-induced cardiotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and miRNA-34a-mediated mechanisms involving multiple cardioprotective signaling pathways.

N. Aldabaan, Basel A. Abdel-Wahab, Ehab A. M. El-Shoura et al. · Immunopharmacology and immun... · 0 citations

Open access Sep 2026

Obeticholic Acid and Edaravone Protect Against Cisplatin‐Induced Hepatotoxicity Through Modulation of Keap1/Nrf2/ARE, TNF‐α/NF‐κB, and AKT/GSK‐3β Pathways

ABSTRACT Hepatotoxicity is one of the most crucial side effects of chemotherapy administration. Obeticholic acid (OCA) is a semisynthetic bile acid and farnesoid X receptor (FXR) agonist derived from chenodeoxycholic acid, with reported antioxidant and anti‐inflammatory effects in liver disorders. This study investigat...

Fares E. M. Ali, Adel G. Bakr, Abdel-Gawad S. Shalkami et al. · Journal of biochemical and m... · 0 citations