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Author

Eiji Yamamoto

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Sep 2026

Cooperative Membrane Recognition by Lipid-Sensing and Kinase Domains Shapes Membrane-Bound States of AKT

The PI3K/AKT signaling pathway is triggered by the recruitment of AKT to cellular membranes. Although AKT is a multidomain serine/threonine kinase composed of an N-terminal pleckstrin homology (PH) domain and a C-terminal kinase domain (KD), how these domains cooperate to regulate AKT activation on membranes remains...

Yuki Nakagaki, Toshiki Mori, Kenichi G. N. Suzuki et al. · 0 citations
Open access Aug 2026

Coarse-grained models for simulations of double-stranded nucleic acids for mixed protein–nucleic acid condensates

A set of coarse-grained two-bead-per-nucleotide models for simulations of double-stranded RNA and DNA in the CALVADOS framework are presented and it is envisioned that the CALVADOS models for double-stranded RNA and DNA will be useful for studying co-condensates of proteins and structured nucleic acids.

Ikki Yasuda, G. Tesei, Eiji Yamamoto et al. · 0 citations

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