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The Tumour Immune Microenvironment in Glioblastoma: Implications for Immunotherapy Failure and Future Directions
Glioblastoma accounts for 14.5% of all central nervous system (CNS) tumours. Current immunotherapeutic strategies include surgery, radiotherapy, and chemotherapy, with an increased focus on checkpoint inhibitors and CAR-T cell therapy. However, these have demonstrated limited clinical effectiveness due to the tumour’s...