Metabolic reprogramming and immune evasion are hallmarks of cancer. Although leucine is well known for regulating protein synthesis, its role in immunometabolic interactions within the tumor microenvironment (TME) remains unclear. In this study, we found that leucine supplementation significantly inhibited tumor growth...
Aflatoxins (AFs), toxic secondary metabolites primarily produced by Aspergillus flavus and A. parasiticus, remain a serious global health challenge due to both acute and particularly chronic toxicity. Unlike acute toxicity, chronic low-dose exposure to AFs is insidious and cumulative, leading to long-term effects such...
Zi-Ying Huang, Chun Xie, Guang Yang et al.· Pharmacological Research· 0 citations
The pivotal roles of biomarkers in SCLC are highlighted, underscoring their contributions to treatment resistance across tumor-intrinsic mechanisms, immune landscape of the tumor microenvironment (TME) and systemic host factors.
Shu-Xing Wang, Xin-rui Zhao, Yue-Yue Zeng et al.· Critical reviews in oncology...· 0 citations
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