Acute rheumatic fever is an immune-mediated sequela of Streptococcus pyogenes (group A Streptococcus) infection, presenting with fever, arthritis, chorea, rash, and, crucially, carditis. Without effective secondary prophylaxis and care, acute rheumatic fever can progress to chronic rheumatic heart disease, a leading ye...
Adrien Lupieri, Juan Manuel Díaz, T. B. Moreira et al.· The Lancet Microbe· 0 citations
Proinflammatory activation of macrophages promotes various inflammatory disorders. The molecular mechanisms underlying macrophage activation, particularly in the context of nuclear translocation of proinflammatory response mediators, remain obscure. We have used a systems approach to explore key regulators of macrophag...
Current knowledge on the roles of noncoding RNAs in regulating macrophage function in atherosclerosis and CKD is discussed, with particular emphasis on the molecular mechanisms underlying inflammatory responses and disease progression.
P. Jha, Caio Borges Nascimento, Adrien Lupieri et al.· Frontiers in Cardiovascular...· 0 citations
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