Author

Elena Marcello

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Review Open access Aug 2026

GLP-1 receptor agonists for Alzheimer’s disease: Lessons from trials and translational challenges

Although GLP-1 receptor agonists show strong mechanistic rationale and supportive epidemiological signals for neuroprotection, large randomized trials in symptomatic AD have yielded negative clinical outcomes and do not support the therapeutic use in AD.

R. Stringhi, Alessandro Padovani, Elena Marcello · Cell Reports Medicine · 0 citations

Open access Jul 2026

Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons

Mapping the spatiotemporal dynamics of PS exposure in mature hippocampal neurons under physiological and pathological conditions using time-lapse imaging reveals specific PS externalization hotspots at dendritic branching points, presenting a potential target for neuroprotective strategies in neurodegeneration.

Adriana Schneider, Alexandra B. Merkel, Nunzio Perta et al. · Cell Death and Disease · 0 citations