Sep 2026
MCC950-Derived NLRP3 Inflammasome Inhibitor Modulates Glial Inflammatory Signatures and Neuroinflammation after Traumatic Brain Injury
It is demonstrated that compound 4b exerts NLRP3 inhibitory activity in CNS-resident innate immune cells and modulates neuroinflammation and functional recovery after TBI, supporting its further development as a mechanistically validated NLRP3 inhibitor with translational relevance.
Céline Decouty-Pérez, María Álvarez-Rubal, Icíar Polo-Fernández et al.
· ACS Pharmacology & Trans... · 0 citations