Crowding governs resistance confinement and guides the improvement of adaptive therapy in a 2D melanoma model system
The emergence of treatment resistant mutants is one of the primary contributors to therapy failure in cancer. Evolution-based adaptive therapies aim to exploit the competition between sensitive and resistant cells to prolong therapeutic control. However, in the densely packed tissues of solid tumors, competition is not...
Jona Kayser, Maximilian Eiche, Elias Ferdinand Fischer et al.
· bioRxiv (Cold Spring Harbor... · 0 citations