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Author

Elisa Federici

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Jul 2026

Abstract B014: Therapeutic Reversal of Tumor Cell Plasticity by EHF mRNA Delivery in Prostate Cancer

This strategy represents a first-in-class opportunity to target tumor plasticity and overcome resistance in advanced prostate cancer with a defined biomarker framework (low EHF expression, plasticity signatures) and compatibility with various delivery platforms.

D. Albino, C. Musumeci, Elisa Storelli et al. · 0 citations
Jul 2026

Abstract B094: Suppressing ERG-driven oncogenesis by mRNA-based delivery of an intracellular mini-body targeting a unique protein methylation site in ERG fusion-positive prostate cancer

The feasibility and efficacy of this novel mini-body-based strategy as a viable therapeutic modality for targeting an oncogenic transcription factor previously considered undruggable are established and supports further translational development for targeting ERG-driven prostate cancer.

C. Musumeci, Concetta Guerra, D. Albino et al. · 0 citations

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