Adaptive siderophore repression and redox-metabolic remodeling limit E. coli Fenton-mediated cytotoxicity after H2O2 exposure
Hydrogen peroxide imposes linked redox and metal stress on bacteria by promoting ferrous iron-dependent Fenton chemistry, generating reactive species that damage DNA, proteins, iron-sulfur cofactors, and membranes. Because siderophores expand iron acquisition, their continued production during peroxide exposure may inc...