Author

Elizabeth A. Spear

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Open access Aug 2026

A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance

ABSTRACT Orthoflavivirus RNA genomes resist host 5′–3′ exoribonucleases to produce subgenomic flaviviral RNAs (sfRNAs). This resistance is conferred by exoribonuclease-resistant RNA (xrRNA) structures within the viral 3′ untranslated region that often occur in tandem, and whose function can be coupled. In dengue virus...

Elizabeth A. Spear, Z. O’Donoghue, Steve L. Bonilla et al. · mBio · 0 citations

Open access Sep 2026

HIGH DOSE GAMMAHERPESVIRUS INFECTION IN MACROPHAGES RESULTS IN INFLAMMATORY MULTIMODAL CELL DEATH

Human gammaherpesviruses (yHVs) including Epstein-Barr Virus and Kaposi’s sarcoma associated herpesvirus are linked to cancer and inflammatory disease development. The outcome of yHV infection is highly regulated by cell type, with macrophages identified as an important early infection target that can also serve as a l...

Gabrielle Vragel, Gracyn Nelson-Reid, Rachael E. Kostelecky et al. · bioRxiv · 0 citations