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Elizabeth K. Wren

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Open access Sep 2026

Structural basis for tetraspanin-dependent surface export and adhesive function of integrin α3β1

Integrin α3β1 (ITGα3β1) is a member of an integrin subfamily that binds to laminin proteins and promotes attachment of epithelial cells to the basement membrane. ITGα3β1 forms a complex with the tetraspanin CD151, and loss-of-function mutations in both ITGα3 and CD151 cause epidermolysis bullosa, a severe skin blisteri...

L. Litzau, Elizabeth K. Wren, Andrew C. Kruse et al. · 0 citations

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