Antiviral Activity of Nirmatrelvir Against Contemporary SARS-CoV-2 Variants.
Nirmatrelvir, the active antiviral component of Paxlovid®, was evaluated for potency against 20 genetically diverse and clinically relevant SARS-CoV-2 variants circulating between 2020 and 2024. Robust in vitro antiviral activity was demonstrated against all tested variants, with only modest reductions in susceptibilit...