Ella Martin

Decoding PIP signaling: structure and catalytic mechanisms of the human phosphoinositide 5-phosphatases.

Phosphoinositides (PIPs) are low-abundance membrane lipids that define organelle identity and regulate intracellular signaling and membrane trafficking events. Their functional diversity arises from reversible phosphorylation of the inositol ring, generating distinct lipid species that act as spatial and temporal signa...