Elyar Bafandeh Zendeh

PeakATail: precision-first poly(A)-site calling and calibrated alternative polyadenylation analysis in single-cell RNA-seq

The tool PeakATail is introduced, which calls polyadenylation sites from reads still carrying a piece of the tail, ranks them by how many distinct molecules carry that evidence, discards sites where adenosine-rich genomic sequence mimics a tail, and pairs them with a differential test whose error rate is measured, not...