Discovery of 1,4-diaryl-1,3-dihydro-2H-imidazole-2-thione anticonvulsants integrating AMPA receptor antagonism, Nav1.2 channel blockade, redox modulation, and favorable pharmacokinetic properties.
A series of 1,4-diaryl-1,3-dihydro-2H-imidazole-2-thione derivatives was designed and synthesized as anticonvulsant candidates, integrating AMPAR antagonism, neuronal Nav1.2 channel blockade, and antioxidant neuroprotection. Biological screening identified compound 6a as the lead analogue, producing complete protection...