Open access
Oct 2026
A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy
Genetically modified immune effector cells, including chimeric antigen receptor (CAR) T cells, have emerged as transformative anti-cancer agents. However, these autonomous, living therapies are limited by difficult-to-control hyperactivation toxicities. To achieve their full potential as therapies for a broader range o...
Ditsa Sarkar, William Lin, Nelson H. Knudsen et al.
· bioRxiv · 0 citations