Background Antinuclear antibodies (ANA) are detected in cancer patients before ICI therapy, but their association with immune-related adverse events (irAEs) and outcomes is uncertain. This study aimed to characterize irAEs and tolerability in ANA-positive patients receiving ICI ± chemotherapy, and explore implications...
Hang-Hui Yu, En-Yong Dai, Jian-Peng Xing et al.· Frontiers in Immunology· 0 citations
Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assem...
Yuan-Qiang Lin, Mingran Dai, En-Yong Dai et al.· Advancement of science· 0 citations
The Wnt11/PCP/YAP axis is identified as a dual driver of CRC malignant progression and immune evasion, providing a mechanistic basis for targeted therapies and immunotherapy combination strategies.
Shi-Bao Wang, Heng-Yu Cai, En-Yong Dai et al.· International Immunopharmaco...· 0 citations
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