Author

Engin Demirdizen

2 papers indexed here

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Open access Sep 2026

Uncovering pan-cancer signatures of chemoresistance

Chemotherapy resistance remains a formidable challenge in cancer treatment, driving high mortality rates worldwide. Despite significant advancements, it remains unclear whether conserved molecular programs underpin therapy resistance across cancer types. Here, we integrate single-cell RNA sequencing, spatial transcript...

Mohammed M. A. Inayatullah, Engin Demirdizen, Z. Keepers et al. · Genome Medicine · 0 citations

Open access Aug 2026

Targeting PRMT5 Inhibitor–Induced Adaptation in Pancreatic Cancer with the RBM39 Degrader Indisulam

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable clinical challenge. Next-generation protein arginine methyltransferase 5 (PRMT5) inhibitors show promising clinical results in a subset of PDACs with codeletion of the tumor-suppressor CDKN2A and the methylthioadenosine phosphorylase (MTAP) gene, but...

Valentina Spielmann, Jonas Buchloh, Selen Selcen et al. · Cancer Research Communicatio... · 0 citations