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Author

Enrica Pellegrino

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Open access Jul 2026

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

It is shown that LRRK2 G2019S has an effect during lysosomal damage through kinase-dependent and kinase-independent mechanisms, and isogenic induced pluripotent stem cells from patients carrying the LRRK2 G2019S variant confirmed that LRRK2 G2019S macrophages are more susceptible to cell death in a kinase-independent m...

Rebecca Morrison, Simeon R. Mihaylov, Chak-Hon Luk et al. · 1 citation

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